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Catecholamine response is attenuated during moderate-intensity exercise in response to the “lactate clamp”
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| Zeitschriftentitel: | American Journal of Physiology-Endocrinology and Metabolism |
|---|---|
| Personen und Körperschaften: | , , , |
| In: | American Journal of Physiology-Endocrinology and Metabolism, 288, 2005, 1, S. E143-E147 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
American Physiological Society
|
| Schlagwörter: |
| author_facet |
Fattor, Jill A. Miller, Benjamin F. Jacobs, Kevin A. Brooks, George A. Fattor, Jill A. Miller, Benjamin F. Jacobs, Kevin A. Brooks, George A. |
|---|---|
| author |
Fattor, Jill A. Miller, Benjamin F. Jacobs, Kevin A. Brooks, George A. |
| spellingShingle |
Fattor, Jill A. Miller, Benjamin F. Jacobs, Kevin A. Brooks, George A. American Journal of Physiology-Endocrinology and Metabolism Catecholamine response is attenuated during moderate-intensity exercise in response to the “lactate clamp” Physiology (medical) Physiology Endocrinology, Diabetes and Metabolism |
| author_sort |
fattor, jill a. |
| spelling |
Fattor, Jill A. Miller, Benjamin F. Jacobs, Kevin A. Brooks, George A. 0193-1849 1522-1555 American Physiological Society Physiology (medical) Physiology Endocrinology, Diabetes and Metabolism http://dx.doi.org/10.1152/ajpendo.00117.2004 <jats:p> Catecholamine release is known to be regulated by feedforward and feedback mechanisms. Norepinephrine (NE) and epinephrine (Epi) concentrations rise in response to stresses, such as exercise, that challenge blood glucose homeostasis. The purpose of this study was to assess the hypothesis that the lactate anion is involved in feedback control of catecholamine concentration. Six healthy active men (26 ± 2 yr, 82 ± 2 kg, 50.7 ± 2.1 ml·kg<jats:sup>−1</jats:sup>·min<jats:sup>−1</jats:sup>) were studied on five occasions after an overnight fast. Plasma concentrations of NE and Epi were determined during 90 min of rest and 90 min of exercise at 55% of peak O<jats:sub>2</jats:sub> consumption (V̇o<jats:sub>2 peak</jats:sub>) two times with exogenous lactate infusion (lactate clamp, LC) and two times without LC (CON). The blood lactate profile (∼4 mM) of a preliminary trial at 65% V̇o<jats:sub>2 peak</jats:sub> (65%) was matched during the subsequent LC trials. In resting men, plasma NE concentration was not different between trials, but during exercise all conditions were different with 65% > CON > LC (65%: 2,115 ± 166 pg/ml, CON: 1,573 ± 153 pg/ml, LC: 930 ± 174 pg/ml, P < 0.05). Plasma Epi concentrations at rest were different between conditions, with LC less than 65% and CON (65%: 68 ± 9 pg/ml, CON: 59 ± 7 pg/ml, LC: 38 ± 10 pg/ml, P < 0.05). During exercise, Epi concentration showed the same trend (65%: 262 ± 37 pg/ml, CON: 190 ± 34 pg/ml, LC: 113.2 ± 23 pg/ml, P < 0.05). In conclusion, lactate attenuates the catecholamine response during moderate-intensity exercise, likely by feedback inhibition. </jats:p> Catecholamine response is attenuated during moderate-intensity exercise in response to the “lactate clamp” American Journal of Physiology-Endocrinology and Metabolism |
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| title |
Catecholamine response is attenuated during moderate-intensity exercise in response to the “lactate clamp” |
| title_unstemmed |
Catecholamine response is attenuated during moderate-intensity exercise in response to the “lactate clamp” |
| title_full |
Catecholamine response is attenuated during moderate-intensity exercise in response to the “lactate clamp” |
| title_fullStr |
Catecholamine response is attenuated during moderate-intensity exercise in response to the “lactate clamp” |
| title_full_unstemmed |
Catecholamine response is attenuated during moderate-intensity exercise in response to the “lactate clamp” |
| title_short |
Catecholamine response is attenuated during moderate-intensity exercise in response to the “lactate clamp” |
| title_sort |
catecholamine response is attenuated during moderate-intensity exercise in response to the “lactate clamp” |
| topic |
Physiology (medical) Physiology Endocrinology, Diabetes and Metabolism |
| url |
http://dx.doi.org/10.1152/ajpendo.00117.2004 |
| publishDate |
2005 |
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E143-E147 |
| description |
<jats:p> Catecholamine release is known to be regulated by feedforward and feedback mechanisms. Norepinephrine (NE) and epinephrine (Epi) concentrations rise in response to stresses, such as exercise, that challenge blood glucose homeostasis. The purpose of this study was to assess the hypothesis that the lactate anion is involved in feedback control of catecholamine concentration. Six healthy active men (26 ± 2 yr, 82 ± 2 kg, 50.7 ± 2.1 ml·kg<jats:sup>−1</jats:sup>·min<jats:sup>−1</jats:sup>) were studied on five occasions after an overnight fast. Plasma concentrations of NE and Epi were determined during 90 min of rest and 90 min of exercise at 55% of peak O<jats:sub>2</jats:sub> consumption (V̇o<jats:sub>2 peak</jats:sub>) two times with exogenous lactate infusion (lactate clamp, LC) and two times without LC (CON). The blood lactate profile (∼4 mM) of a preliminary trial at 65% V̇o<jats:sub>2 peak</jats:sub> (65%) was matched during the subsequent LC trials. In resting men, plasma NE concentration was not different between trials, but during exercise all conditions were different with 65% > CON > LC (65%: 2,115 ± 166 pg/ml, CON: 1,573 ± 153 pg/ml, LC: 930 ± 174 pg/ml, P < 0.05). Plasma Epi concentrations at rest were different between conditions, with LC less than 65% and CON (65%: 68 ± 9 pg/ml, CON: 59 ± 7 pg/ml, LC: 38 ± 10 pg/ml, P < 0.05). During exercise, Epi concentration showed the same trend (65%: 262 ± 37 pg/ml, CON: 190 ± 34 pg/ml, LC: 113.2 ± 23 pg/ml, P < 0.05). In conclusion, lactate attenuates the catecholamine response during moderate-intensity exercise, likely by feedback inhibition. </jats:p> |
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| author | Fattor, Jill A., Miller, Benjamin F., Jacobs, Kevin A., Brooks, George A. |
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| description | <jats:p> Catecholamine release is known to be regulated by feedforward and feedback mechanisms. Norepinephrine (NE) and epinephrine (Epi) concentrations rise in response to stresses, such as exercise, that challenge blood glucose homeostasis. The purpose of this study was to assess the hypothesis that the lactate anion is involved in feedback control of catecholamine concentration. Six healthy active men (26 ± 2 yr, 82 ± 2 kg, 50.7 ± 2.1 ml·kg<jats:sup>−1</jats:sup>·min<jats:sup>−1</jats:sup>) were studied on five occasions after an overnight fast. Plasma concentrations of NE and Epi were determined during 90 min of rest and 90 min of exercise at 55% of peak O<jats:sub>2</jats:sub> consumption (V̇o<jats:sub>2 peak</jats:sub>) two times with exogenous lactate infusion (lactate clamp, LC) and two times without LC (CON). The blood lactate profile (∼4 mM) of a preliminary trial at 65% V̇o<jats:sub>2 peak</jats:sub> (65%) was matched during the subsequent LC trials. In resting men, plasma NE concentration was not different between trials, but during exercise all conditions were different with 65% > CON > LC (65%: 2,115 ± 166 pg/ml, CON: 1,573 ± 153 pg/ml, LC: 930 ± 174 pg/ml, P < 0.05). Plasma Epi concentrations at rest were different between conditions, with LC less than 65% and CON (65%: 68 ± 9 pg/ml, CON: 59 ± 7 pg/ml, LC: 38 ± 10 pg/ml, P < 0.05). During exercise, Epi concentration showed the same trend (65%: 262 ± 37 pg/ml, CON: 190 ± 34 pg/ml, LC: 113.2 ± 23 pg/ml, P < 0.05). In conclusion, lactate attenuates the catecholamine response during moderate-intensity exercise, likely by feedback inhibition. </jats:p> |
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| spelling | Fattor, Jill A. Miller, Benjamin F. Jacobs, Kevin A. Brooks, George A. 0193-1849 1522-1555 American Physiological Society Physiology (medical) Physiology Endocrinology, Diabetes and Metabolism http://dx.doi.org/10.1152/ajpendo.00117.2004 <jats:p> Catecholamine release is known to be regulated by feedforward and feedback mechanisms. Norepinephrine (NE) and epinephrine (Epi) concentrations rise in response to stresses, such as exercise, that challenge blood glucose homeostasis. The purpose of this study was to assess the hypothesis that the lactate anion is involved in feedback control of catecholamine concentration. Six healthy active men (26 ± 2 yr, 82 ± 2 kg, 50.7 ± 2.1 ml·kg<jats:sup>−1</jats:sup>·min<jats:sup>−1</jats:sup>) were studied on five occasions after an overnight fast. Plasma concentrations of NE and Epi were determined during 90 min of rest and 90 min of exercise at 55% of peak O<jats:sub>2</jats:sub> consumption (V̇o<jats:sub>2 peak</jats:sub>) two times with exogenous lactate infusion (lactate clamp, LC) and two times without LC (CON). The blood lactate profile (∼4 mM) of a preliminary trial at 65% V̇o<jats:sub>2 peak</jats:sub> (65%) was matched during the subsequent LC trials. In resting men, plasma NE concentration was not different between trials, but during exercise all conditions were different with 65% > CON > LC (65%: 2,115 ± 166 pg/ml, CON: 1,573 ± 153 pg/ml, LC: 930 ± 174 pg/ml, P < 0.05). Plasma Epi concentrations at rest were different between conditions, with LC less than 65% and CON (65%: 68 ± 9 pg/ml, CON: 59 ± 7 pg/ml, LC: 38 ± 10 pg/ml, P < 0.05). During exercise, Epi concentration showed the same trend (65%: 262 ± 37 pg/ml, CON: 190 ± 34 pg/ml, LC: 113.2 ± 23 pg/ml, P < 0.05). In conclusion, lactate attenuates the catecholamine response during moderate-intensity exercise, likely by feedback inhibition. </jats:p> Catecholamine response is attenuated during moderate-intensity exercise in response to the “lactate clamp” American Journal of Physiology-Endocrinology and Metabolism |
| spellingShingle | Fattor, Jill A., Miller, Benjamin F., Jacobs, Kevin A., Brooks, George A., American Journal of Physiology-Endocrinology and Metabolism, Catecholamine response is attenuated during moderate-intensity exercise in response to the “lactate clamp”, Physiology (medical), Physiology, Endocrinology, Diabetes and Metabolism |
| title | Catecholamine response is attenuated during moderate-intensity exercise in response to the “lactate clamp” |
| title_full | Catecholamine response is attenuated during moderate-intensity exercise in response to the “lactate clamp” |
| title_fullStr | Catecholamine response is attenuated during moderate-intensity exercise in response to the “lactate clamp” |
| title_full_unstemmed | Catecholamine response is attenuated during moderate-intensity exercise in response to the “lactate clamp” |
| title_short | Catecholamine response is attenuated during moderate-intensity exercise in response to the “lactate clamp” |
| title_sort | catecholamine response is attenuated during moderate-intensity exercise in response to the “lactate clamp” |
| title_unstemmed | Catecholamine response is attenuated during moderate-intensity exercise in response to the “lactate clamp” |
| topic | Physiology (medical), Physiology, Endocrinology, Diabetes and Metabolism |
| url | http://dx.doi.org/10.1152/ajpendo.00117.2004 |