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Translation of Anticancer Efficacy From Nonclinical Models to the Clinic
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| Zeitschriftentitel: | CPT: Pharmacometrics & Systems Pharmacology |
|---|---|
| Personen und Körperschaften: | , , , , |
| In: | CPT: Pharmacometrics & Systems Pharmacology, 3, 2014, 8, S. 1-4 |
| Format: | E-Article |
| Sprache: | Englisch |
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Wiley
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Stroh, M Duda, DG Takimoto, CH Yamazaki, S Vicini, P Stroh, M Duda, DG Takimoto, CH Yamazaki, S Vicini, P |
|---|---|
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Stroh, M Duda, DG Takimoto, CH Yamazaki, S Vicini, P |
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Stroh, M Duda, DG Takimoto, CH Yamazaki, S Vicini, P CPT: Pharmacometrics & Systems Pharmacology Translation of Anticancer Efficacy From Nonclinical Models to the Clinic Pharmacology (medical) Modeling and Simulation |
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stroh, m |
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Stroh, M Duda, DG Takimoto, CH Yamazaki, S Vicini, P 2163-8306 2163-8306 Wiley Pharmacology (medical) Modeling and Simulation http://dx.doi.org/10.1038/psp.2014.28 <jats:p>Mouse cancer models have provided critical insights into tumor biology; however, clinical translation of these findings has been challenging. This perspective posits that factors impacting on successful translation start with limitations in capturing human cancer pathophysiology and end with challenges in generating robust translatable preclinical end points. A comprehensive approach that considers clinically relevant mouse models with both an integrated biomarker strategy and a complementary modeling and simulation effort will strengthen the current oncology drug development paradigm.</jats:p><jats:p><jats:italic>CPT Pharmacometrics Syst. Pharmacol</jats:italic>. (2014) 3, e128; doi:<jats:ext-link xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" xlink:href="10.1038/psp.2014.28">10.1038/psp.2014.28</jats:ext-link>; published online 06 August 2014</jats:p> Translation of Anticancer Efficacy From Nonclinical Models to the Clinic CPT: Pharmacometrics & Systems Pharmacology |
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| title |
Translation of Anticancer Efficacy From Nonclinical Models to the Clinic |
| title_unstemmed |
Translation of Anticancer Efficacy From Nonclinical Models to the Clinic |
| title_full |
Translation of Anticancer Efficacy From Nonclinical Models to the Clinic |
| title_fullStr |
Translation of Anticancer Efficacy From Nonclinical Models to the Clinic |
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Translation of Anticancer Efficacy From Nonclinical Models to the Clinic |
| title_short |
Translation of Anticancer Efficacy From Nonclinical Models to the Clinic |
| title_sort |
translation of anticancer efficacy from nonclinical models to the clinic |
| topic |
Pharmacology (medical) Modeling and Simulation |
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http://dx.doi.org/10.1038/psp.2014.28 |
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2014 |
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<jats:p>Mouse cancer models have provided critical insights into tumor biology; however, clinical translation of these findings has been challenging. This perspective posits that factors impacting on successful translation start with limitations in capturing human cancer pathophysiology and end with challenges in generating robust translatable preclinical end points. A comprehensive approach that considers clinically relevant mouse models with both an integrated biomarker strategy and a complementary modeling and simulation effort will strengthen the current oncology drug development paradigm.</jats:p><jats:p><jats:italic>CPT Pharmacometrics Syst. Pharmacol</jats:italic>. (2014) 3, e128; doi:<jats:ext-link xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" xlink:href="10.1038/psp.2014.28">10.1038/psp.2014.28</jats:ext-link>; published online 06 August 2014</jats:p> |
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| description | <jats:p>Mouse cancer models have provided critical insights into tumor biology; however, clinical translation of these findings has been challenging. This perspective posits that factors impacting on successful translation start with limitations in capturing human cancer pathophysiology and end with challenges in generating robust translatable preclinical end points. A comprehensive approach that considers clinically relevant mouse models with both an integrated biomarker strategy and a complementary modeling and simulation effort will strengthen the current oncology drug development paradigm.</jats:p><jats:p><jats:italic>CPT Pharmacometrics Syst. Pharmacol</jats:italic>. (2014) 3, e128; doi:<jats:ext-link xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" xlink:href="10.1038/psp.2014.28">10.1038/psp.2014.28</jats:ext-link>; published online 06 August 2014</jats:p> |
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| spelling | Stroh, M Duda, DG Takimoto, CH Yamazaki, S Vicini, P 2163-8306 2163-8306 Wiley Pharmacology (medical) Modeling and Simulation http://dx.doi.org/10.1038/psp.2014.28 <jats:p>Mouse cancer models have provided critical insights into tumor biology; however, clinical translation of these findings has been challenging. This perspective posits that factors impacting on successful translation start with limitations in capturing human cancer pathophysiology and end with challenges in generating robust translatable preclinical end points. A comprehensive approach that considers clinically relevant mouse models with both an integrated biomarker strategy and a complementary modeling and simulation effort will strengthen the current oncology drug development paradigm.</jats:p><jats:p><jats:italic>CPT Pharmacometrics Syst. Pharmacol</jats:italic>. (2014) 3, e128; doi:<jats:ext-link xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" xlink:href="10.1038/psp.2014.28">10.1038/psp.2014.28</jats:ext-link>; published online 06 August 2014</jats:p> Translation of Anticancer Efficacy From Nonclinical Models to the Clinic CPT: Pharmacometrics & Systems Pharmacology |
| spellingShingle | Stroh, M, Duda, DG, Takimoto, CH, Yamazaki, S, Vicini, P, CPT: Pharmacometrics & Systems Pharmacology, Translation of Anticancer Efficacy From Nonclinical Models to the Clinic, Pharmacology (medical), Modeling and Simulation |
| title | Translation of Anticancer Efficacy From Nonclinical Models to the Clinic |
| title_full | Translation of Anticancer Efficacy From Nonclinical Models to the Clinic |
| title_fullStr | Translation of Anticancer Efficacy From Nonclinical Models to the Clinic |
| title_full_unstemmed | Translation of Anticancer Efficacy From Nonclinical Models to the Clinic |
| title_short | Translation of Anticancer Efficacy From Nonclinical Models to the Clinic |
| title_sort | translation of anticancer efficacy from nonclinical models to the clinic |
| title_unstemmed | Translation of Anticancer Efficacy From Nonclinical Models to the Clinic |
| topic | Pharmacology (medical), Modeling and Simulation |
| url | http://dx.doi.org/10.1038/psp.2014.28 |