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Cortactin expression: Association with disease progression and survival in oral squamous cell carcinoma
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| Název časopisu: | Head & Neck |
|---|---|
| Personen und Körperschaften: | , , , , , , , , , , , |
| In: | Head & Neck, 40, 2018, 12, s. 2685-2694 |
| Formát: | Článek |
| Jazyk: | angličtina |
| vydáno v: |
Wiley
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| Předměty: |
| author_facet |
Horn, Dominik Gross, Madeleine Dyckhoff, Gerhard Fuchs, Jennifer Grabe, Niels Weichert, Wilko Herpel, Esther Herold‐Mende, Christel Lichter, Peter Hoffmann, Jürgen Hess, Jochen Freier, Kolja Horn, Dominik Gross, Madeleine Dyckhoff, Gerhard Fuchs, Jennifer Grabe, Niels Weichert, Wilko Herpel, Esther Herold‐Mende, Christel Lichter, Peter Hoffmann, Jürgen Hess, Jochen Freier, Kolja |
|---|---|
| author |
Horn, Dominik Gross, Madeleine Dyckhoff, Gerhard Fuchs, Jennifer Grabe, Niels Weichert, Wilko Herpel, Esther Herold‐Mende, Christel Lichter, Peter Hoffmann, Jürgen Hess, Jochen Freier, Kolja |
| spellingShingle |
Horn, Dominik Gross, Madeleine Dyckhoff, Gerhard Fuchs, Jennifer Grabe, Niels Weichert, Wilko Herpel, Esther Herold‐Mende, Christel Lichter, Peter Hoffmann, Jürgen Hess, Jochen Freier, Kolja Head & Neck Cortactin expression: Association with disease progression and survival in oral squamous cell carcinoma Otorhinolaryngology |
| author_sort |
horn, dominik |
| spelling |
Horn, Dominik Gross, Madeleine Dyckhoff, Gerhard Fuchs, Jennifer Grabe, Niels Weichert, Wilko Herpel, Esther Herold‐Mende, Christel Lichter, Peter Hoffmann, Jürgen Hess, Jochen Freier, Kolja 1043-3074 1097-0347 Wiley Otorhinolaryngology http://dx.doi.org/10.1002/hed.25515 <jats:title>Abstract</jats:title><jats:sec><jats:title>Background</jats:title><jats:p>Cortactin (CTTN) is located on chromosome 11q13 and is associated with invasiveness in various cancer entities. CTTN protein expression could be a prognosticator of oral squamous cell carcinoma (OSCC) in terms of recurrence and survival.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>CTTN‐dependent invasion was performed using migration assay in human papillomavirus‐negative head and neck squamous cell carcinoma (HNSCC) cells. Cortactin protein analysis in tissue microarrays was used for correlation with clinical parameters, as well as for survival analysis. Gene expression profiling in HNSCC cells was performed to unreveal CTTN signaling.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>Knockdown of CTTN in HNSCC cells showed less invasion in vitro. Gene expression profiling showed various deregulated genes known to be involved in progression. We confirmed the link between CTTN overexpression and progression in a large clinical cohort. High expression was associated with worse overall and progression‐free survival.</jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p>We propose CTTN for managing OSCC in terms of adjuvant therapy and aftercare. Furthermore, our study reveals new potential targets in CTTN signaling for individualized OSCC therapy.</jats:p></jats:sec> Cortactin expression: Association with disease progression and survival in oral squamous cell carcinoma Head & Neck |
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10.1002/hed.25515 |
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Wiley, 2018 |
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Wiley, 2018 |
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1043-3074 1097-0347 |
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| title |
Cortactin expression: Association with disease progression and survival in oral squamous cell carcinoma |
| title_unstemmed |
Cortactin expression: Association with disease progression and survival in oral squamous cell carcinoma |
| title_full |
Cortactin expression: Association with disease progression and survival in oral squamous cell carcinoma |
| title_fullStr |
Cortactin expression: Association with disease progression and survival in oral squamous cell carcinoma |
| title_full_unstemmed |
Cortactin expression: Association with disease progression and survival in oral squamous cell carcinoma |
| title_short |
Cortactin expression: Association with disease progression and survival in oral squamous cell carcinoma |
| title_sort |
cortactin expression: association with disease progression and survival in oral squamous cell carcinoma |
| topic |
Otorhinolaryngology |
| url |
http://dx.doi.org/10.1002/hed.25515 |
| publishDate |
2018 |
| physical |
2685-2694 |
| description |
<jats:title>Abstract</jats:title><jats:sec><jats:title>Background</jats:title><jats:p>Cortactin (CTTN) is located on chromosome 11q13 and is associated with invasiveness in various cancer entities. CTTN protein expression could be a prognosticator of oral squamous cell carcinoma (OSCC) in terms of recurrence and survival.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>CTTN‐dependent invasion was performed using migration assay in human papillomavirus‐negative head and neck squamous cell carcinoma (HNSCC) cells. Cortactin protein analysis in tissue microarrays was used for correlation with clinical parameters, as well as for survival analysis. Gene expression profiling in HNSCC cells was performed to unreveal CTTN signaling.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>Knockdown of CTTN in HNSCC cells showed less invasion in vitro. Gene expression profiling showed various deregulated genes known to be involved in progression. We confirmed the link between CTTN overexpression and progression in a large clinical cohort. High expression was associated with worse overall and progression‐free survival.</jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p>We propose CTTN for managing OSCC in terms of adjuvant therapy and aftercare. Furthermore, our study reveals new potential targets in CTTN signaling for individualized OSCC therapy.</jats:p></jats:sec> |
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| author | Horn, Dominik, Gross, Madeleine, Dyckhoff, Gerhard, Fuchs, Jennifer, Grabe, Niels, Weichert, Wilko, Herpel, Esther, Herold‐Mende, Christel, Lichter, Peter, Hoffmann, Jürgen, Hess, Jochen, Freier, Kolja |
| author_facet | Horn, Dominik, Gross, Madeleine, Dyckhoff, Gerhard, Fuchs, Jennifer, Grabe, Niels, Weichert, Wilko, Herpel, Esther, Herold‐Mende, Christel, Lichter, Peter, Hoffmann, Jürgen, Hess, Jochen, Freier, Kolja, Horn, Dominik, Gross, Madeleine, Dyckhoff, Gerhard, Fuchs, Jennifer, Grabe, Niels, Weichert, Wilko, Herpel, Esther, Herold‐Mende, Christel, Lichter, Peter, Hoffmann, Jürgen, Hess, Jochen, Freier, Kolja |
| author_sort | horn, dominik |
| container_issue | 12 |
| container_start_page | 2685 |
| container_title | Head & Neck |
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| description | <jats:title>Abstract</jats:title><jats:sec><jats:title>Background</jats:title><jats:p>Cortactin (CTTN) is located on chromosome 11q13 and is associated with invasiveness in various cancer entities. CTTN protein expression could be a prognosticator of oral squamous cell carcinoma (OSCC) in terms of recurrence and survival.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>CTTN‐dependent invasion was performed using migration assay in human papillomavirus‐negative head and neck squamous cell carcinoma (HNSCC) cells. Cortactin protein analysis in tissue microarrays was used for correlation with clinical parameters, as well as for survival analysis. Gene expression profiling in HNSCC cells was performed to unreveal CTTN signaling.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>Knockdown of CTTN in HNSCC cells showed less invasion in vitro. Gene expression profiling showed various deregulated genes known to be involved in progression. We confirmed the link between CTTN overexpression and progression in a large clinical cohort. High expression was associated with worse overall and progression‐free survival.</jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p>We propose CTTN for managing OSCC in terms of adjuvant therapy and aftercare. Furthermore, our study reveals new potential targets in CTTN signaling for individualized OSCC therapy.</jats:p></jats:sec> |
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| imprint | Wiley, 2018 |
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| institution | DE-15, DE-Rs1, DE-Pl11, DE-105, DE-14, DE-Ch1, DE-L229, DE-D275, DE-Bn3, DE-Brt1, DE-D161, DE-Gla1, DE-Zi4 |
| issn | 1043-3074, 1097-0347 |
| issn_str_mv | 1043-3074, 1097-0347 |
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| spelling | Horn, Dominik Gross, Madeleine Dyckhoff, Gerhard Fuchs, Jennifer Grabe, Niels Weichert, Wilko Herpel, Esther Herold‐Mende, Christel Lichter, Peter Hoffmann, Jürgen Hess, Jochen Freier, Kolja 1043-3074 1097-0347 Wiley Otorhinolaryngology http://dx.doi.org/10.1002/hed.25515 <jats:title>Abstract</jats:title><jats:sec><jats:title>Background</jats:title><jats:p>Cortactin (CTTN) is located on chromosome 11q13 and is associated with invasiveness in various cancer entities. CTTN protein expression could be a prognosticator of oral squamous cell carcinoma (OSCC) in terms of recurrence and survival.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>CTTN‐dependent invasion was performed using migration assay in human papillomavirus‐negative head and neck squamous cell carcinoma (HNSCC) cells. Cortactin protein analysis in tissue microarrays was used for correlation with clinical parameters, as well as for survival analysis. Gene expression profiling in HNSCC cells was performed to unreveal CTTN signaling.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>Knockdown of CTTN in HNSCC cells showed less invasion in vitro. Gene expression profiling showed various deregulated genes known to be involved in progression. We confirmed the link between CTTN overexpression and progression in a large clinical cohort. High expression was associated with worse overall and progression‐free survival.</jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p>We propose CTTN for managing OSCC in terms of adjuvant therapy and aftercare. Furthermore, our study reveals new potential targets in CTTN signaling for individualized OSCC therapy.</jats:p></jats:sec> Cortactin expression: Association with disease progression and survival in oral squamous cell carcinoma Head & Neck |
| spellingShingle | Horn, Dominik, Gross, Madeleine, Dyckhoff, Gerhard, Fuchs, Jennifer, Grabe, Niels, Weichert, Wilko, Herpel, Esther, Herold‐Mende, Christel, Lichter, Peter, Hoffmann, Jürgen, Hess, Jochen, Freier, Kolja, Head & Neck, Cortactin expression: Association with disease progression and survival in oral squamous cell carcinoma, Otorhinolaryngology |
| title | Cortactin expression: Association with disease progression and survival in oral squamous cell carcinoma |
| title_full | Cortactin expression: Association with disease progression and survival in oral squamous cell carcinoma |
| title_fullStr | Cortactin expression: Association with disease progression and survival in oral squamous cell carcinoma |
| title_full_unstemmed | Cortactin expression: Association with disease progression and survival in oral squamous cell carcinoma |
| title_short | Cortactin expression: Association with disease progression and survival in oral squamous cell carcinoma |
| title_sort | cortactin expression: association with disease progression and survival in oral squamous cell carcinoma |
| title_unstemmed | Cortactin expression: Association with disease progression and survival in oral squamous cell carcinoma |
| topic | Otorhinolaryngology |
| url | http://dx.doi.org/10.1002/hed.25515 |