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Increased frequency of vβ17‐positive t cells in patients with rheumatoid arthritis
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| Zeitschriftentitel: | Arthritis & Rheumatism |
|---|---|
| Personen und Körperschaften: | , , , , |
| In: | Arthritis & Rheumatism, 37, 1994, 10, S. 1431-1440 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Wiley
|
| Schlagwörter: |
| author_facet |
Zagon, Gary Tumang, Joseph R. Li, Yixin Friedman, Steven M. Crow, Mary K. Zagon, Gary Tumang, Joseph R. Li, Yixin Friedman, Steven M. Crow, Mary K. |
|---|---|
| author |
Zagon, Gary Tumang, Joseph R. Li, Yixin Friedman, Steven M. Crow, Mary K. |
| spellingShingle |
Zagon, Gary Tumang, Joseph R. Li, Yixin Friedman, Steven M. Crow, Mary K. Arthritis & Rheumatism Increased frequency of vβ17‐positive t cells in patients with rheumatoid arthritis Pharmacology (medical) Immunology Rheumatology Immunology and Allergy |
| author_sort |
zagon, gary |
| spelling |
Zagon, Gary Tumang, Joseph R. Li, Yixin Friedman, Steven M. Crow, Mary K. 0004-3591 1529-0131 Wiley Pharmacology (medical) Immunology Rheumatology Immunology and Allergy http://dx.doi.org/10.1002/art.1780371005 <jats:title>Abstract</jats:title><jats:p><jats:italic>Objective</jats:italic>. To identify the T lymphocytes that mediate disease in rheumatoid arthritis (RA).</jats:p><jats:p><jats:italic>Methods</jats:italic>. A panel of monoclonal antibodies reactive with T cell receptor (TCR) Vβ gene products was used to analyze the RA T cell repertoire.</jats:p><jats:p><jats:italic>Results</jats:italic>. Of 5 TCR Vβ gene products studied, only Vβ17‐positive T cells were increased in peripheral blood and synovial fluid (SF) from RA patients, compared with controls (<jats:italic>P</jats:italic> < 0.01 and <jats:italic>P</jats:italic> = 0.0006, respectively). Thirty‐one percent of the 49 RA SF samples and none of the 19 non‐RA SF samples contained >10% Vβ17‐positive T cells. Activated (Tac‐positive) T cells were enriched among Vβ17‐positive synovial T cells.</jats:p><jats:p><jats:italic>Conclusion</jats:italic>. The selective increase of Vβ17‐positive T cells suggests a role for those T cells in the pathogenesis of RA.</jats:p> Increased frequency of vβ17‐positive t cells in patients with rheumatoid arthritis Arthritis & Rheumatism |
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Increased frequency of vβ17‐positive t cells in patients with rheumatoid arthritis |
| title_unstemmed |
Increased frequency of vβ17‐positive t cells in patients with rheumatoid arthritis |
| title_full |
Increased frequency of vβ17‐positive t cells in patients with rheumatoid arthritis |
| title_fullStr |
Increased frequency of vβ17‐positive t cells in patients with rheumatoid arthritis |
| title_full_unstemmed |
Increased frequency of vβ17‐positive t cells in patients with rheumatoid arthritis |
| title_short |
Increased frequency of vβ17‐positive t cells in patients with rheumatoid arthritis |
| title_sort |
increased frequency of vβ17‐positive t cells in patients with rheumatoid arthritis |
| topic |
Pharmacology (medical) Immunology Rheumatology Immunology and Allergy |
| url |
http://dx.doi.org/10.1002/art.1780371005 |
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1994 |
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1431-1440 |
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<jats:title>Abstract</jats:title><jats:p><jats:italic>Objective</jats:italic>. To identify the T lymphocytes that mediate disease in rheumatoid arthritis (RA).</jats:p><jats:p><jats:italic>Methods</jats:italic>. A panel of monoclonal antibodies reactive with T cell receptor (TCR) Vβ gene products was used to analyze the RA T cell repertoire.</jats:p><jats:p><jats:italic>Results</jats:italic>. Of 5 TCR Vβ gene products studied, only Vβ17‐positive T cells were increased in peripheral blood and synovial fluid (SF) from RA patients, compared with controls (<jats:italic>P</jats:italic> < 0.01 and <jats:italic>P</jats:italic> = 0.0006, respectively). Thirty‐one percent of the 49 RA SF samples and none of the 19 non‐RA SF samples contained >10% Vβ17‐positive T cells. Activated (Tac‐positive) T cells were enriched among Vβ17‐positive synovial T cells.</jats:p><jats:p><jats:italic>Conclusion</jats:italic>. The selective increase of Vβ17‐positive T cells suggests a role for those T cells in the pathogenesis of RA.</jats:p> |
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| author | Zagon, Gary, Tumang, Joseph R., Li, Yixin, Friedman, Steven M., Crow, Mary K. |
| author_facet | Zagon, Gary, Tumang, Joseph R., Li, Yixin, Friedman, Steven M., Crow, Mary K., Zagon, Gary, Tumang, Joseph R., Li, Yixin, Friedman, Steven M., Crow, Mary K. |
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| description | <jats:title>Abstract</jats:title><jats:p><jats:italic>Objective</jats:italic>. To identify the T lymphocytes that mediate disease in rheumatoid arthritis (RA).</jats:p><jats:p><jats:italic>Methods</jats:italic>. A panel of monoclonal antibodies reactive with T cell receptor (TCR) Vβ gene products was used to analyze the RA T cell repertoire.</jats:p><jats:p><jats:italic>Results</jats:italic>. Of 5 TCR Vβ gene products studied, only Vβ17‐positive T cells were increased in peripheral blood and synovial fluid (SF) from RA patients, compared with controls (<jats:italic>P</jats:italic> < 0.01 and <jats:italic>P</jats:italic> = 0.0006, respectively). Thirty‐one percent of the 49 RA SF samples and none of the 19 non‐RA SF samples contained >10% Vβ17‐positive T cells. Activated (Tac‐positive) T cells were enriched among Vβ17‐positive synovial T cells.</jats:p><jats:p><jats:italic>Conclusion</jats:italic>. The selective increase of Vβ17‐positive T cells suggests a role for those T cells in the pathogenesis of RA.</jats:p> |
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| imprint | Wiley, 1994 |
| imprint_str_mv | Wiley, 1994 |
| institution | DE-Gla1, DE-Zi4, DE-15, DE-Pl11, DE-Rs1, DE-105, DE-14, DE-Ch1, DE-L229, DE-D275, DE-Bn3, DE-Brt1, DE-Zwi2, DE-D161 |
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| spelling | Zagon, Gary Tumang, Joseph R. Li, Yixin Friedman, Steven M. Crow, Mary K. 0004-3591 1529-0131 Wiley Pharmacology (medical) Immunology Rheumatology Immunology and Allergy http://dx.doi.org/10.1002/art.1780371005 <jats:title>Abstract</jats:title><jats:p><jats:italic>Objective</jats:italic>. To identify the T lymphocytes that mediate disease in rheumatoid arthritis (RA).</jats:p><jats:p><jats:italic>Methods</jats:italic>. A panel of monoclonal antibodies reactive with T cell receptor (TCR) Vβ gene products was used to analyze the RA T cell repertoire.</jats:p><jats:p><jats:italic>Results</jats:italic>. Of 5 TCR Vβ gene products studied, only Vβ17‐positive T cells were increased in peripheral blood and synovial fluid (SF) from RA patients, compared with controls (<jats:italic>P</jats:italic> < 0.01 and <jats:italic>P</jats:italic> = 0.0006, respectively). Thirty‐one percent of the 49 RA SF samples and none of the 19 non‐RA SF samples contained >10% Vβ17‐positive T cells. Activated (Tac‐positive) T cells were enriched among Vβ17‐positive synovial T cells.</jats:p><jats:p><jats:italic>Conclusion</jats:italic>. The selective increase of Vβ17‐positive T cells suggests a role for those T cells in the pathogenesis of RA.</jats:p> Increased frequency of vβ17‐positive t cells in patients with rheumatoid arthritis Arthritis & Rheumatism |
| spellingShingle | Zagon, Gary, Tumang, Joseph R., Li, Yixin, Friedman, Steven M., Crow, Mary K., Arthritis & Rheumatism, Increased frequency of vβ17‐positive t cells in patients with rheumatoid arthritis, Pharmacology (medical), Immunology, Rheumatology, Immunology and Allergy |
| title | Increased frequency of vβ17‐positive t cells in patients with rheumatoid arthritis |
| title_full | Increased frequency of vβ17‐positive t cells in patients with rheumatoid arthritis |
| title_fullStr | Increased frequency of vβ17‐positive t cells in patients with rheumatoid arthritis |
| title_full_unstemmed | Increased frequency of vβ17‐positive t cells in patients with rheumatoid arthritis |
| title_short | Increased frequency of vβ17‐positive t cells in patients with rheumatoid arthritis |
| title_sort | increased frequency of vβ17‐positive t cells in patients with rheumatoid arthritis |
| title_unstemmed | Increased frequency of vβ17‐positive t cells in patients with rheumatoid arthritis |
| topic | Pharmacology (medical), Immunology, Rheumatology, Immunology and Allergy |
| url | http://dx.doi.org/10.1002/art.1780371005 |