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Association of ADH1B Arg47His polymorphism with the risk of cancer: a meta-analysis
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| Zeitschriftentitel: | Bioscience Reports |
|---|---|
| Personen und Körperschaften: | , |
| In: | Bioscience Reports, 39, 2019, 4 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Portland Press Ltd.
|
| Schlagwörter: |
| author_facet |
Tan, Boyu Ning, Ning Tan, Boyu Ning, Ning |
|---|---|
| author |
Tan, Boyu Ning, Ning |
| spellingShingle |
Tan, Boyu Ning, Ning Bioscience Reports Association of ADH1B Arg47His polymorphism with the risk of cancer: a meta-analysis Cell Biology Molecular Biology Biochemistry Biophysics |
| author_sort |
tan, boyu |
| spelling |
Tan, Boyu Ning, Ning 0144-8463 1573-4935 Portland Press Ltd. Cell Biology Molecular Biology Biochemistry Biophysics http://dx.doi.org/10.1042/bsr20181915 <jats:title>Abstract</jats:title> <jats:p>Alcohol consumption has been established to be a major factor in the development and progress of cancer. Genetic polymorphisms of alcohol-metabolism genes result in differences between individuals in exposure to acetaldehyde, leading to possible carcinogenic effects. Arg47His (rs1229984 G &gt; A) in ADH1B have been frequently studied for its potential effect on carcinogenesis. However, the findings are as yet inconclusive. To gain a more precise estimate of this potential association, we conducted a meta-analysis including 66 studies from 64 articles with 31999 cases and 50964 controls. The pooled results indicated that ADH1B Arg47His polymorphism is significantly associated with the decreased risk of overall cancer (homozygous model, odds ratio (OR) = 0.62, 95% confidence interval (CI) = 0.49–0.77; heterozygous model, OR = 0.71, 95% CI = 0.60–0.84; recessive model, OR = 0.83, 95% CI = 0.76–0.91; dominant model, OR = 0.62, 95% CI = 0.53–0.72; and allele comparison, OR = 0.82, 95% CI = 0.75–0.89). Stratified analysis by cancer type and ethnicity showed that a decreased risk was associated with esophageal cancer and head and neck cancer amongst Asians. In conclusion, our meta-analysis suggested that ADH1B Arg47His polymorphism was significantly associated with decreased overall cancer risk. These findings need further validation in large multicenter investigations.</jats:p> Association of <i>ADH1B</i> Arg47His polymorphism with the risk of cancer: a meta-analysis Bioscience Reports |
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| title |
Association of ADH1B Arg47His polymorphism with the risk of cancer: a meta-analysis |
| title_unstemmed |
Association of ADH1B Arg47His polymorphism with the risk of cancer: a meta-analysis |
| title_full |
Association of ADH1B Arg47His polymorphism with the risk of cancer: a meta-analysis |
| title_fullStr |
Association of ADH1B Arg47His polymorphism with the risk of cancer: a meta-analysis |
| title_full_unstemmed |
Association of ADH1B Arg47His polymorphism with the risk of cancer: a meta-analysis |
| title_short |
Association of ADH1B Arg47His polymorphism with the risk of cancer: a meta-analysis |
| title_sort |
association of <i>adh1b</i> arg47his polymorphism with the risk of cancer: a meta-analysis |
| topic |
Cell Biology Molecular Biology Biochemistry Biophysics |
| url |
http://dx.doi.org/10.1042/bsr20181915 |
| publishDate |
2019 |
| physical |
|
| description |
<jats:title>Abstract</jats:title>
<jats:p>Alcohol consumption has been established to be a major factor in the development and progress of cancer. Genetic polymorphisms of alcohol-metabolism genes result in differences between individuals in exposure to acetaldehyde, leading to possible carcinogenic effects. Arg47His (rs1229984 G &gt; A) in ADH1B have been frequently studied for its potential effect on carcinogenesis. However, the findings are as yet inconclusive. To gain a more precise estimate of this potential association, we conducted a meta-analysis including 66 studies from 64 articles with 31999 cases and 50964 controls. The pooled results indicated that ADH1B Arg47His polymorphism is significantly associated with the decreased risk of overall cancer (homozygous model, odds ratio (OR) = 0.62, 95% confidence interval (CI) = 0.49–0.77; heterozygous model, OR = 0.71, 95% CI = 0.60–0.84; recessive model, OR = 0.83, 95% CI = 0.76–0.91; dominant model, OR = 0.62, 95% CI = 0.53–0.72; and allele comparison, OR = 0.82, 95% CI = 0.75–0.89). Stratified analysis by cancer type and ethnicity showed that a decreased risk was associated with esophageal cancer and head and neck cancer amongst Asians. In conclusion, our meta-analysis suggested that ADH1B Arg47His polymorphism was significantly associated with decreased overall cancer risk. These findings need further validation in large multicenter investigations.</jats:p> |
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| description | <jats:title>Abstract</jats:title> <jats:p>Alcohol consumption has been established to be a major factor in the development and progress of cancer. Genetic polymorphisms of alcohol-metabolism genes result in differences between individuals in exposure to acetaldehyde, leading to possible carcinogenic effects. Arg47His (rs1229984 G &gt; A) in ADH1B have been frequently studied for its potential effect on carcinogenesis. However, the findings are as yet inconclusive. To gain a more precise estimate of this potential association, we conducted a meta-analysis including 66 studies from 64 articles with 31999 cases and 50964 controls. The pooled results indicated that ADH1B Arg47His polymorphism is significantly associated with the decreased risk of overall cancer (homozygous model, odds ratio (OR) = 0.62, 95% confidence interval (CI) = 0.49–0.77; heterozygous model, OR = 0.71, 95% CI = 0.60–0.84; recessive model, OR = 0.83, 95% CI = 0.76–0.91; dominant model, OR = 0.62, 95% CI = 0.53–0.72; and allele comparison, OR = 0.82, 95% CI = 0.75–0.89). Stratified analysis by cancer type and ethnicity showed that a decreased risk was associated with esophageal cancer and head and neck cancer amongst Asians. In conclusion, our meta-analysis suggested that ADH1B Arg47His polymorphism was significantly associated with decreased overall cancer risk. These findings need further validation in large multicenter investigations.</jats:p> |
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| spelling | Tan, Boyu Ning, Ning 0144-8463 1573-4935 Portland Press Ltd. Cell Biology Molecular Biology Biochemistry Biophysics http://dx.doi.org/10.1042/bsr20181915 <jats:title>Abstract</jats:title> <jats:p>Alcohol consumption has been established to be a major factor in the development and progress of cancer. Genetic polymorphisms of alcohol-metabolism genes result in differences between individuals in exposure to acetaldehyde, leading to possible carcinogenic effects. Arg47His (rs1229984 G &gt; A) in ADH1B have been frequently studied for its potential effect on carcinogenesis. However, the findings are as yet inconclusive. To gain a more precise estimate of this potential association, we conducted a meta-analysis including 66 studies from 64 articles with 31999 cases and 50964 controls. The pooled results indicated that ADH1B Arg47His polymorphism is significantly associated with the decreased risk of overall cancer (homozygous model, odds ratio (OR) = 0.62, 95% confidence interval (CI) = 0.49–0.77; heterozygous model, OR = 0.71, 95% CI = 0.60–0.84; recessive model, OR = 0.83, 95% CI = 0.76–0.91; dominant model, OR = 0.62, 95% CI = 0.53–0.72; and allele comparison, OR = 0.82, 95% CI = 0.75–0.89). Stratified analysis by cancer type and ethnicity showed that a decreased risk was associated with esophageal cancer and head and neck cancer amongst Asians. In conclusion, our meta-analysis suggested that ADH1B Arg47His polymorphism was significantly associated with decreased overall cancer risk. These findings need further validation in large multicenter investigations.</jats:p> Association of <i>ADH1B</i> Arg47His polymorphism with the risk of cancer: a meta-analysis Bioscience Reports |
| spellingShingle | Tan, Boyu, Ning, Ning, Bioscience Reports, Association of ADH1B Arg47His polymorphism with the risk of cancer: a meta-analysis, Cell Biology, Molecular Biology, Biochemistry, Biophysics |
| title | Association of ADH1B Arg47His polymorphism with the risk of cancer: a meta-analysis |
| title_full | Association of ADH1B Arg47His polymorphism with the risk of cancer: a meta-analysis |
| title_fullStr | Association of ADH1B Arg47His polymorphism with the risk of cancer: a meta-analysis |
| title_full_unstemmed | Association of ADH1B Arg47His polymorphism with the risk of cancer: a meta-analysis |
| title_short | Association of ADH1B Arg47His polymorphism with the risk of cancer: a meta-analysis |
| title_sort | association of <i>adh1b</i> arg47his polymorphism with the risk of cancer: a meta-analysis |
| title_unstemmed | Association of ADH1B Arg47His polymorphism with the risk of cancer: a meta-analysis |
| topic | Cell Biology, Molecular Biology, Biochemistry, Biophysics |
| url | http://dx.doi.org/10.1042/bsr20181915 |