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Investigation of ICOS, CD28 and CD80 polymorphisms with the risk of hepatocellular carcinoma: a case–control study in eastern Chinese population
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| Zeitschriftentitel: | Bioscience Reports |
|---|---|
| Personen und Körperschaften: | , , , , , , |
| In: | Bioscience Reports, 39, 2019, 7 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Portland Press Ltd.
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| Schlagwörter: |
| author_facet |
Yang, Jing Liu, Jiaochun Chen, Yu Tang, Weifeng Bo, Kai Sun, Yuling Chen, Jianping Yang, Jing Liu, Jiaochun Chen, Yu Tang, Weifeng Bo, Kai Sun, Yuling Chen, Jianping |
|---|---|
| author |
Yang, Jing Liu, Jiaochun Chen, Yu Tang, Weifeng Bo, Kai Sun, Yuling Chen, Jianping |
| spellingShingle |
Yang, Jing Liu, Jiaochun Chen, Yu Tang, Weifeng Bo, Kai Sun, Yuling Chen, Jianping Bioscience Reports Investigation of ICOS, CD28 and CD80 polymorphisms with the risk of hepatocellular carcinoma: a case–control study in eastern Chinese population Cell Biology Molecular Biology Biochemistry Biophysics |
| author_sort |
yang, jing |
| spelling |
Yang, Jing Liu, Jiaochun Chen, Yu Tang, Weifeng Bo, Kai Sun, Yuling Chen, Jianping 0144-8463 1573-4935 Portland Press Ltd. Cell Biology Molecular Biology Biochemistry Biophysics http://dx.doi.org/10.1042/bsr20181824 <jats:title>Abstract</jats:title> <jats:p>Single nucleotide polymorphisms (SNPs) in immune related gene may influence the susceptibility of cancer. We selected inducible T cell costimulator (ICOS) rs4404254 T&gt;C, rs10932029 T&gt;C, CD28 rs3116496 T&gt;C and CD80 rs7628626 C&gt;A SNPs and assessed the potential relationship of these SNPs with hepatocellular carcinoma (HCC) risk. A total of 584 HCC cases and 923 healthy controls were recruited. And SNPscan™ genotyping assay was used to obtain the genotypes of ICOS, CD28 and CD80 polymorphisms. We found that ICOS rs10932029 T&gt;C polymorphism significantly increased the risk of HCC (additive model: adjusted odds ratio (OR), 1.59; 95% confidence interval (CI), 1.13–2.22; P=0.007; homozygote model: adjusted OR, 1.12; 95% CI, 0.31–4.03; P=0.867; dominant model: adjusted OR, 1.58; 95% CI, 1.14–2.19; P=0.007 and recessive model: adjusted OR, 1.02; 95% CI, 0.28–3.68; P=0.974). However, ICOS rs4404254 T&gt;C, CD28 rs3116496 T&gt;C and CD80 rs7628626 C&gt;A SNPs were not associated with the risk of HCC. To evaluate the effects of ICOS rs10932029 T&gt;C on HCC risk according to different age, gender, chronic hepatitis B virus (HBV) infection, tobacco consumption and drinking status, we carried out a stratification analysis. We found that ICOS rs10932029 T&gt;C polymorphism might increase the risk of HCC in male, ≥53 years, never smoking, never drinking and non-chronic HBV infection subgroups. Our study highlights that ICOS rs10932029 T&gt;C polymorphism may confer the susceptibility to HCC. It may be beneficial to explore the relationship between variants in immune related genes and the development of HCC.</jats:p> Investigation of <i>ICOS, CD28</i> and <i>CD80</i> polymorphisms with the risk of hepatocellular carcinoma: a case–control study in eastern Chinese population Bioscience Reports |
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| title |
Investigation of ICOS, CD28 and CD80 polymorphisms with the risk of hepatocellular carcinoma: a case–control study in eastern Chinese population |
| title_unstemmed |
Investigation of ICOS, CD28 and CD80 polymorphisms with the risk of hepatocellular carcinoma: a case–control study in eastern Chinese population |
| title_full |
Investigation of ICOS, CD28 and CD80 polymorphisms with the risk of hepatocellular carcinoma: a case–control study in eastern Chinese population |
| title_fullStr |
Investigation of ICOS, CD28 and CD80 polymorphisms with the risk of hepatocellular carcinoma: a case–control study in eastern Chinese population |
| title_full_unstemmed |
Investigation of ICOS, CD28 and CD80 polymorphisms with the risk of hepatocellular carcinoma: a case–control study in eastern Chinese population |
| title_short |
Investigation of ICOS, CD28 and CD80 polymorphisms with the risk of hepatocellular carcinoma: a case–control study in eastern Chinese population |
| title_sort |
investigation of <i>icos, cd28</i> and <i>cd80</i> polymorphisms with the risk of hepatocellular carcinoma: a case–control study in eastern chinese population |
| topic |
Cell Biology Molecular Biology Biochemistry Biophysics |
| url |
http://dx.doi.org/10.1042/bsr20181824 |
| publishDate |
2019 |
| physical |
|
| description |
<jats:title>Abstract</jats:title>
<jats:p>Single nucleotide polymorphisms (SNPs) in immune related gene may influence the susceptibility of cancer. We selected inducible T cell costimulator (ICOS) rs4404254 T&gt;C, rs10932029 T&gt;C, CD28 rs3116496 T&gt;C and CD80 rs7628626 C&gt;A SNPs and assessed the potential relationship of these SNPs with hepatocellular carcinoma (HCC) risk. A total of 584 HCC cases and 923 healthy controls were recruited. And SNPscan™ genotyping assay was used to obtain the genotypes of ICOS, CD28 and CD80 polymorphisms. We found that ICOS rs10932029 T&gt;C polymorphism significantly increased the risk of HCC (additive model: adjusted odds ratio (OR), 1.59; 95% confidence interval (CI), 1.13–2.22; P=0.007; homozygote model: adjusted OR, 1.12; 95% CI, 0.31–4.03; P=0.867; dominant model: adjusted OR, 1.58; 95% CI, 1.14–2.19; P=0.007 and recessive model: adjusted OR, 1.02; 95% CI, 0.28–3.68; P=0.974). However, ICOS rs4404254 T&gt;C, CD28 rs3116496 T&gt;C and CD80 rs7628626 C&gt;A SNPs were not associated with the risk of HCC. To evaluate the effects of ICOS rs10932029 T&gt;C on HCC risk according to different age, gender, chronic hepatitis B virus (HBV) infection, tobacco consumption and drinking status, we carried out a stratification analysis. We found that ICOS rs10932029 T&gt;C polymorphism might increase the risk of HCC in male, ≥53 years, never smoking, never drinking and non-chronic HBV infection subgroups. Our study highlights that ICOS rs10932029 T&gt;C polymorphism may confer the susceptibility to HCC. It may be beneficial to explore the relationship between variants in immune related genes and the development of HCC.</jats:p> |
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| author | Yang, Jing, Liu, Jiaochun, Chen, Yu, Tang, Weifeng, Bo, Kai, Sun, Yuling, Chen, Jianping |
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| description | <jats:title>Abstract</jats:title> <jats:p>Single nucleotide polymorphisms (SNPs) in immune related gene may influence the susceptibility of cancer. We selected inducible T cell costimulator (ICOS) rs4404254 T&gt;C, rs10932029 T&gt;C, CD28 rs3116496 T&gt;C and CD80 rs7628626 C&gt;A SNPs and assessed the potential relationship of these SNPs with hepatocellular carcinoma (HCC) risk. A total of 584 HCC cases and 923 healthy controls were recruited. And SNPscan™ genotyping assay was used to obtain the genotypes of ICOS, CD28 and CD80 polymorphisms. We found that ICOS rs10932029 T&gt;C polymorphism significantly increased the risk of HCC (additive model: adjusted odds ratio (OR), 1.59; 95% confidence interval (CI), 1.13–2.22; P=0.007; homozygote model: adjusted OR, 1.12; 95% CI, 0.31–4.03; P=0.867; dominant model: adjusted OR, 1.58; 95% CI, 1.14–2.19; P=0.007 and recessive model: adjusted OR, 1.02; 95% CI, 0.28–3.68; P=0.974). However, ICOS rs4404254 T&gt;C, CD28 rs3116496 T&gt;C and CD80 rs7628626 C&gt;A SNPs were not associated with the risk of HCC. To evaluate the effects of ICOS rs10932029 T&gt;C on HCC risk according to different age, gender, chronic hepatitis B virus (HBV) infection, tobacco consumption and drinking status, we carried out a stratification analysis. We found that ICOS rs10932029 T&gt;C polymorphism might increase the risk of HCC in male, ≥53 years, never smoking, never drinking and non-chronic HBV infection subgroups. Our study highlights that ICOS rs10932029 T&gt;C polymorphism may confer the susceptibility to HCC. It may be beneficial to explore the relationship between variants in immune related genes and the development of HCC.</jats:p> |
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| institution | DE-Zwi2, DE-D161, DE-Gla1, DE-Zi4, DE-15, DE-Pl11, DE-Rs1, DE-105, DE-14, DE-Ch1, DE-L229, DE-D275, DE-Bn3, DE-Brt1 |
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| spelling | Yang, Jing Liu, Jiaochun Chen, Yu Tang, Weifeng Bo, Kai Sun, Yuling Chen, Jianping 0144-8463 1573-4935 Portland Press Ltd. Cell Biology Molecular Biology Biochemistry Biophysics http://dx.doi.org/10.1042/bsr20181824 <jats:title>Abstract</jats:title> <jats:p>Single nucleotide polymorphisms (SNPs) in immune related gene may influence the susceptibility of cancer. We selected inducible T cell costimulator (ICOS) rs4404254 T&gt;C, rs10932029 T&gt;C, CD28 rs3116496 T&gt;C and CD80 rs7628626 C&gt;A SNPs and assessed the potential relationship of these SNPs with hepatocellular carcinoma (HCC) risk. A total of 584 HCC cases and 923 healthy controls were recruited. And SNPscan™ genotyping assay was used to obtain the genotypes of ICOS, CD28 and CD80 polymorphisms. We found that ICOS rs10932029 T&gt;C polymorphism significantly increased the risk of HCC (additive model: adjusted odds ratio (OR), 1.59; 95% confidence interval (CI), 1.13–2.22; P=0.007; homozygote model: adjusted OR, 1.12; 95% CI, 0.31–4.03; P=0.867; dominant model: adjusted OR, 1.58; 95% CI, 1.14–2.19; P=0.007 and recessive model: adjusted OR, 1.02; 95% CI, 0.28–3.68; P=0.974). However, ICOS rs4404254 T&gt;C, CD28 rs3116496 T&gt;C and CD80 rs7628626 C&gt;A SNPs were not associated with the risk of HCC. To evaluate the effects of ICOS rs10932029 T&gt;C on HCC risk according to different age, gender, chronic hepatitis B virus (HBV) infection, tobacco consumption and drinking status, we carried out a stratification analysis. We found that ICOS rs10932029 T&gt;C polymorphism might increase the risk of HCC in male, ≥53 years, never smoking, never drinking and non-chronic HBV infection subgroups. Our study highlights that ICOS rs10932029 T&gt;C polymorphism may confer the susceptibility to HCC. It may be beneficial to explore the relationship between variants in immune related genes and the development of HCC.</jats:p> Investigation of <i>ICOS, CD28</i> and <i>CD80</i> polymorphisms with the risk of hepatocellular carcinoma: a case–control study in eastern Chinese population Bioscience Reports |
| spellingShingle | Yang, Jing, Liu, Jiaochun, Chen, Yu, Tang, Weifeng, Bo, Kai, Sun, Yuling, Chen, Jianping, Bioscience Reports, Investigation of ICOS, CD28 and CD80 polymorphisms with the risk of hepatocellular carcinoma: a case–control study in eastern Chinese population, Cell Biology, Molecular Biology, Biochemistry, Biophysics |
| title | Investigation of ICOS, CD28 and CD80 polymorphisms with the risk of hepatocellular carcinoma: a case–control study in eastern Chinese population |
| title_full | Investigation of ICOS, CD28 and CD80 polymorphisms with the risk of hepatocellular carcinoma: a case–control study in eastern Chinese population |
| title_fullStr | Investigation of ICOS, CD28 and CD80 polymorphisms with the risk of hepatocellular carcinoma: a case–control study in eastern Chinese population |
| title_full_unstemmed | Investigation of ICOS, CD28 and CD80 polymorphisms with the risk of hepatocellular carcinoma: a case–control study in eastern Chinese population |
| title_short | Investigation of ICOS, CD28 and CD80 polymorphisms with the risk of hepatocellular carcinoma: a case–control study in eastern Chinese population |
| title_sort | investigation of <i>icos, cd28</i> and <i>cd80</i> polymorphisms with the risk of hepatocellular carcinoma: a case–control study in eastern chinese population |
| title_unstemmed | Investigation of ICOS, CD28 and CD80 polymorphisms with the risk of hepatocellular carcinoma: a case–control study in eastern Chinese population |
| topic | Cell Biology, Molecular Biology, Biochemistry, Biophysics |
| url | http://dx.doi.org/10.1042/bsr20181824 |