Eintrag weiter verarbeiten
miR-500 promotes cell proliferation by directly targetting LRP1B in prostate cancer
Gespeichert in:
| Zeitschriftentitel: | Bioscience Reports |
|---|---|
| Personen und Körperschaften: | , , , |
| In: | Bioscience Reports, 39, 2019, 4 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Portland Press Ltd.
|
| Schlagwörter: |
| author_facet |
Zhang, Zhaoli Cui, Ran Li, Hui Li, Jinlong Zhang, Zhaoli Cui, Ran Li, Hui Li, Jinlong |
|---|---|
| author |
Zhang, Zhaoli Cui, Ran Li, Hui Li, Jinlong |
| spellingShingle |
Zhang, Zhaoli Cui, Ran Li, Hui Li, Jinlong Bioscience Reports miR-500 promotes cell proliferation by directly targetting LRP1B in prostate cancer Cell Biology Molecular Biology Biochemistry Biophysics |
| author_sort |
zhang, zhaoli |
| spelling |
Zhang, Zhaoli Cui, Ran Li, Hui Li, Jinlong 0144-8463 1573-4935 Portland Press Ltd. Cell Biology Molecular Biology Biochemistry Biophysics http://dx.doi.org/10.1042/bsr20181854 <jats:title>Abstract</jats:title> <jats:p>Accumulating evidence suggests that miRNAs play a crucial role in the development of prostate cancer (PC); however, the role of miR-500 in PC remains poorly understood. The data presented here reveal abnormal increases in miR-500 expression in PC tissues and cell lines. Suppression of miR-500 expression significantly inhibited the proliferation of PC-3 and LnCap cells and was negatively regulative with low-density lipoprotein receptor-related protein 1B (LRP1B). Increased cell cycle arrest at the G1 stage and decreased protein expression of cyclinD1 and CDK2 was observed in response to miR-500 knockdown in PC-3 and LnCap cells, in combination with LRP1B overexpression. LRP1B was identified as a target of miR-500 and was significantly decreased in PC tissues. Taken together, these findings demonstrate that miR-500 plays an important role in the proliferation of PC cells via the inhibition of LRP1B expression.</jats:p> miR-500 promotes cell proliferation by directly targetting LRP1B in prostate cancer Bioscience Reports |
| doi_str_mv |
10.1042/bsr20181854 |
| facet_avail |
Online Free |
| finc_class_facet |
Biologie Chemie und Pharmazie Physik |
| format |
ElectronicArticle |
| fullrecord |
blob:ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTA0Mi9ic3IyMDE4MTg1NA |
| id |
ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTA0Mi9ic3IyMDE4MTg1NA |
| institution |
DE-Gla1 DE-Zi4 DE-15 DE-Pl11 DE-Rs1 DE-105 DE-14 DE-Ch1 DE-L229 DE-D275 DE-Bn3 DE-Brt1 DE-D161 DE-Zwi2 |
| imprint |
Portland Press Ltd., 2019 |
| imprint_str_mv |
Portland Press Ltd., 2019 |
| issn |
0144-8463 1573-4935 |
| issn_str_mv |
0144-8463 1573-4935 |
| language |
English |
| mega_collection |
Portland Press Ltd. (CrossRef) |
| match_str |
zhang2019mir500promotescellproliferationbydirectlytargettinglrp1binprostatecancer |
| publishDateSort |
2019 |
| publisher |
Portland Press Ltd. |
| recordtype |
ai |
| record_format |
ai |
| series |
Bioscience Reports |
| source_id |
49 |
| title |
miR-500 promotes cell proliferation by directly targetting LRP1B in prostate cancer |
| title_unstemmed |
miR-500 promotes cell proliferation by directly targetting LRP1B in prostate cancer |
| title_full |
miR-500 promotes cell proliferation by directly targetting LRP1B in prostate cancer |
| title_fullStr |
miR-500 promotes cell proliferation by directly targetting LRP1B in prostate cancer |
| title_full_unstemmed |
miR-500 promotes cell proliferation by directly targetting LRP1B in prostate cancer |
| title_short |
miR-500 promotes cell proliferation by directly targetting LRP1B in prostate cancer |
| title_sort |
mir-500 promotes cell proliferation by directly targetting lrp1b in prostate cancer |
| topic |
Cell Biology Molecular Biology Biochemistry Biophysics |
| url |
http://dx.doi.org/10.1042/bsr20181854 |
| publishDate |
2019 |
| physical |
|
| description |
<jats:title>Abstract</jats:title>
<jats:p>Accumulating evidence suggests that miRNAs play a crucial role in the development of prostate cancer (PC); however, the role of miR-500 in PC remains poorly understood. The data presented here reveal abnormal increases in miR-500 expression in PC tissues and cell lines. Suppression of miR-500 expression significantly inhibited the proliferation of PC-3 and LnCap cells and was negatively regulative with low-density lipoprotein receptor-related protein 1B (LRP1B). Increased cell cycle arrest at the G1 stage and decreased protein expression of cyclinD1 and CDK2 was observed in response to miR-500 knockdown in PC-3 and LnCap cells, in combination with LRP1B overexpression. LRP1B was identified as a target of miR-500 and was significantly decreased in PC tissues. Taken together, these findings demonstrate that miR-500 plays an important role in the proliferation of PC cells via the inhibition of LRP1B expression.</jats:p> |
| container_issue |
4 |
| container_start_page |
0 |
| container_title |
Bioscience Reports |
| container_volume |
39 |
| format_de105 |
Article, E-Article |
| format_de14 |
Article, E-Article |
| format_de15 |
Article, E-Article |
| format_de520 |
Article, E-Article |
| format_de540 |
Article, E-Article |
| format_dech1 |
Article, E-Article |
| format_ded117 |
Article, E-Article |
| format_degla1 |
E-Article |
| format_del152 |
Buch |
| format_del189 |
Article, E-Article |
| format_dezi4 |
Article |
| format_dezwi2 |
Article, E-Article |
| format_finc |
Article, E-Article |
| format_nrw |
Article, E-Article |
| _version_ |
1792331969941471237 |
| geogr_code |
not assigned |
| last_indexed |
2024-03-01T13:48:54.418Z |
| geogr_code_person |
not assigned |
| openURL |
url_ver=Z39.88-2004&ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fvufind.svn.sourceforge.net%3Agenerator&rft.title=miR-500+promotes+cell+proliferation+by+directly+targetting+LRP1B+in+prostate+cancer&rft.date=2019-04-30&genre=article&issn=1573-4935&volume=39&issue=4&jtitle=Bioscience+Reports&atitle=miR-500+promotes+cell+proliferation+by+directly+targetting+LRP1B+in+prostate+cancer&aulast=Li&aufirst=Jinlong&rft_id=info%3Adoi%2F10.1042%2Fbsr20181854&rft.language%5B0%5D=eng |
| SOLR | |
| _version_ | 1792331969941471237 |
| author | Zhang, Zhaoli, Cui, Ran, Li, Hui, Li, Jinlong |
| author_facet | Zhang, Zhaoli, Cui, Ran, Li, Hui, Li, Jinlong, Zhang, Zhaoli, Cui, Ran, Li, Hui, Li, Jinlong |
| author_sort | zhang, zhaoli |
| container_issue | 4 |
| container_start_page | 0 |
| container_title | Bioscience Reports |
| container_volume | 39 |
| description | <jats:title>Abstract</jats:title> <jats:p>Accumulating evidence suggests that miRNAs play a crucial role in the development of prostate cancer (PC); however, the role of miR-500 in PC remains poorly understood. The data presented here reveal abnormal increases in miR-500 expression in PC tissues and cell lines. Suppression of miR-500 expression significantly inhibited the proliferation of PC-3 and LnCap cells and was negatively regulative with low-density lipoprotein receptor-related protein 1B (LRP1B). Increased cell cycle arrest at the G1 stage and decreased protein expression of cyclinD1 and CDK2 was observed in response to miR-500 knockdown in PC-3 and LnCap cells, in combination with LRP1B overexpression. LRP1B was identified as a target of miR-500 and was significantly decreased in PC tissues. Taken together, these findings demonstrate that miR-500 plays an important role in the proliferation of PC cells via the inhibition of LRP1B expression.</jats:p> |
| doi_str_mv | 10.1042/bsr20181854 |
| facet_avail | Online, Free |
| finc_class_facet | Biologie, Chemie und Pharmazie, Physik |
| format | ElectronicArticle |
| format_de105 | Article, E-Article |
| format_de14 | Article, E-Article |
| format_de15 | Article, E-Article |
| format_de520 | Article, E-Article |
| format_de540 | Article, E-Article |
| format_dech1 | Article, E-Article |
| format_ded117 | Article, E-Article |
| format_degla1 | E-Article |
| format_del152 | Buch |
| format_del189 | Article, E-Article |
| format_dezi4 | Article |
| format_dezwi2 | Article, E-Article |
| format_finc | Article, E-Article |
| format_nrw | Article, E-Article |
| geogr_code | not assigned |
| geogr_code_person | not assigned |
| id | ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTA0Mi9ic3IyMDE4MTg1NA |
| imprint | Portland Press Ltd., 2019 |
| imprint_str_mv | Portland Press Ltd., 2019 |
| institution | DE-Gla1, DE-Zi4, DE-15, DE-Pl11, DE-Rs1, DE-105, DE-14, DE-Ch1, DE-L229, DE-D275, DE-Bn3, DE-Brt1, DE-D161, DE-Zwi2 |
| issn | 0144-8463, 1573-4935 |
| issn_str_mv | 0144-8463, 1573-4935 |
| language | English |
| last_indexed | 2024-03-01T13:48:54.418Z |
| match_str | zhang2019mir500promotescellproliferationbydirectlytargettinglrp1binprostatecancer |
| mega_collection | Portland Press Ltd. (CrossRef) |
| physical | |
| publishDate | 2019 |
| publishDateSort | 2019 |
| publisher | Portland Press Ltd. |
| record_format | ai |
| recordtype | ai |
| series | Bioscience Reports |
| source_id | 49 |
| spelling | Zhang, Zhaoli Cui, Ran Li, Hui Li, Jinlong 0144-8463 1573-4935 Portland Press Ltd. Cell Biology Molecular Biology Biochemistry Biophysics http://dx.doi.org/10.1042/bsr20181854 <jats:title>Abstract</jats:title> <jats:p>Accumulating evidence suggests that miRNAs play a crucial role in the development of prostate cancer (PC); however, the role of miR-500 in PC remains poorly understood. The data presented here reveal abnormal increases in miR-500 expression in PC tissues and cell lines. Suppression of miR-500 expression significantly inhibited the proliferation of PC-3 and LnCap cells and was negatively regulative with low-density lipoprotein receptor-related protein 1B (LRP1B). Increased cell cycle arrest at the G1 stage and decreased protein expression of cyclinD1 and CDK2 was observed in response to miR-500 knockdown in PC-3 and LnCap cells, in combination with LRP1B overexpression. LRP1B was identified as a target of miR-500 and was significantly decreased in PC tissues. Taken together, these findings demonstrate that miR-500 plays an important role in the proliferation of PC cells via the inhibition of LRP1B expression.</jats:p> miR-500 promotes cell proliferation by directly targetting LRP1B in prostate cancer Bioscience Reports |
| spellingShingle | Zhang, Zhaoli, Cui, Ran, Li, Hui, Li, Jinlong, Bioscience Reports, miR-500 promotes cell proliferation by directly targetting LRP1B in prostate cancer, Cell Biology, Molecular Biology, Biochemistry, Biophysics |
| title | miR-500 promotes cell proliferation by directly targetting LRP1B in prostate cancer |
| title_full | miR-500 promotes cell proliferation by directly targetting LRP1B in prostate cancer |
| title_fullStr | miR-500 promotes cell proliferation by directly targetting LRP1B in prostate cancer |
| title_full_unstemmed | miR-500 promotes cell proliferation by directly targetting LRP1B in prostate cancer |
| title_short | miR-500 promotes cell proliferation by directly targetting LRP1B in prostate cancer |
| title_sort | mir-500 promotes cell proliferation by directly targetting lrp1b in prostate cancer |
| title_unstemmed | miR-500 promotes cell proliferation by directly targetting LRP1B in prostate cancer |
| topic | Cell Biology, Molecular Biology, Biochemistry, Biophysics |
| url | http://dx.doi.org/10.1042/bsr20181854 |