author_facet Adamson, R. H.
Bridges, J. W.
Evans, M. E.
Williams, R. T.
Adamson, R. H.
Bridges, J. W.
Evans, M. E.
Williams, R. T.
author Adamson, R. H.
Bridges, J. W.
Evans, M. E.
Williams, R. T.
spellingShingle Adamson, R. H.
Bridges, J. W.
Evans, M. E.
Williams, R. T.
Biochemical Journal
Species differences in the aromatization of quinic acid in vivo and the role of gut bacteria
General Medicine
author_sort adamson, r. h.
spelling Adamson, R. H. Bridges, J. W. Evans, M. E. Williams, R. T. 0306-3283 Portland Press Ltd. General Medicine http://dx.doi.org/10.1042/bj1160437 <jats:p>1. The fate of (-)-quinic acid has been investigated in 22 species of animals including man. 2. In man and three species of Old World monkeys, i.e. rhesus monkey, baboon and green monkey, oral quinic acid was extensively aromatized (20–60%) and excreted in the urine as hippuric acid, which was determined fluorimetrically. 3. In three species of New World monkeys, i.e. squirrel monkey, spider monkey and capuchin, in three species of lemurs, i.e. bushbaby, slow loris and tree shrew, in the dog, cat, ferret, rabbit, rat, mouse, guinea pig, hamster, lemming, fruit bat, hedgehog and pigeon, oral quinic acid was not extensively aromatized (0–5%). 4. In the rhesus monkey, injected quinic acid was not aromatized, but largely excreted unchanged. 5. In rhesus monkeys pretreated with neomycin to suppress gut flora, the aromatization of oral quinic acid was considerably suppressed. 6. In rats and rhesus monkeys [14C]quinic acid was used and this confirmed its low aromatization in rats and its high aromatization in the monkeys. 7. Shikimic acid given orally was excreted as hippuric acid (26–56%) in rhesus monkeys, but not in rats. 8. The results support the view that quinic acid and shikimic acid are aromatized by the gut flora in man and the Old World monkeys.</jats:p> Species differences in the aromatization of quinic acid <i>in vivo</i> and the role of gut bacteria Biochemical Journal
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title Species differences in the aromatization of quinic acid in vivo and the role of gut bacteria
title_unstemmed Species differences in the aromatization of quinic acid in vivo and the role of gut bacteria
title_full Species differences in the aromatization of quinic acid in vivo and the role of gut bacteria
title_fullStr Species differences in the aromatization of quinic acid in vivo and the role of gut bacteria
title_full_unstemmed Species differences in the aromatization of quinic acid in vivo and the role of gut bacteria
title_short Species differences in the aromatization of quinic acid in vivo and the role of gut bacteria
title_sort species differences in the aromatization of quinic acid <i>in vivo</i> and the role of gut bacteria
topic General Medicine
url http://dx.doi.org/10.1042/bj1160437
publishDate 1970
physical 437-443
description <jats:p>1. The fate of (-)-quinic acid has been investigated in 22 species of animals including man. 2. In man and three species of Old World monkeys, i.e. rhesus monkey, baboon and green monkey, oral quinic acid was extensively aromatized (20–60%) and excreted in the urine as hippuric acid, which was determined fluorimetrically. 3. In three species of New World monkeys, i.e. squirrel monkey, spider monkey and capuchin, in three species of lemurs, i.e. bushbaby, slow loris and tree shrew, in the dog, cat, ferret, rabbit, rat, mouse, guinea pig, hamster, lemming, fruit bat, hedgehog and pigeon, oral quinic acid was not extensively aromatized (0–5%). 4. In the rhesus monkey, injected quinic acid was not aromatized, but largely excreted unchanged. 5. In rhesus monkeys pretreated with neomycin to suppress gut flora, the aromatization of oral quinic acid was considerably suppressed. 6. In rats and rhesus monkeys [14C]quinic acid was used and this confirmed its low aromatization in rats and its high aromatization in the monkeys. 7. Shikimic acid given orally was excreted as hippuric acid (26–56%) in rhesus monkeys, but not in rats. 8. The results support the view that quinic acid and shikimic acid are aromatized by the gut flora in man and the Old World monkeys.</jats:p>
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author Adamson, R. H., Bridges, J. W., Evans, M. E., Williams, R. T.
author_facet Adamson, R. H., Bridges, J. W., Evans, M. E., Williams, R. T., Adamson, R. H., Bridges, J. W., Evans, M. E., Williams, R. T.
author_sort adamson, r. h.
container_issue 3
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container_title Biochemical Journal
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description <jats:p>1. The fate of (-)-quinic acid has been investigated in 22 species of animals including man. 2. In man and three species of Old World monkeys, i.e. rhesus monkey, baboon and green monkey, oral quinic acid was extensively aromatized (20–60%) and excreted in the urine as hippuric acid, which was determined fluorimetrically. 3. In three species of New World monkeys, i.e. squirrel monkey, spider monkey and capuchin, in three species of lemurs, i.e. bushbaby, slow loris and tree shrew, in the dog, cat, ferret, rabbit, rat, mouse, guinea pig, hamster, lemming, fruit bat, hedgehog and pigeon, oral quinic acid was not extensively aromatized (0–5%). 4. In the rhesus monkey, injected quinic acid was not aromatized, but largely excreted unchanged. 5. In rhesus monkeys pretreated with neomycin to suppress gut flora, the aromatization of oral quinic acid was considerably suppressed. 6. In rats and rhesus monkeys [14C]quinic acid was used and this confirmed its low aromatization in rats and its high aromatization in the monkeys. 7. Shikimic acid given orally was excreted as hippuric acid (26–56%) in rhesus monkeys, but not in rats. 8. The results support the view that quinic acid and shikimic acid are aromatized by the gut flora in man and the Old World monkeys.</jats:p>
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spelling Adamson, R. H. Bridges, J. W. Evans, M. E. Williams, R. T. 0306-3283 Portland Press Ltd. General Medicine http://dx.doi.org/10.1042/bj1160437 <jats:p>1. The fate of (-)-quinic acid has been investigated in 22 species of animals including man. 2. In man and three species of Old World monkeys, i.e. rhesus monkey, baboon and green monkey, oral quinic acid was extensively aromatized (20–60%) and excreted in the urine as hippuric acid, which was determined fluorimetrically. 3. In three species of New World monkeys, i.e. squirrel monkey, spider monkey and capuchin, in three species of lemurs, i.e. bushbaby, slow loris and tree shrew, in the dog, cat, ferret, rabbit, rat, mouse, guinea pig, hamster, lemming, fruit bat, hedgehog and pigeon, oral quinic acid was not extensively aromatized (0–5%). 4. In the rhesus monkey, injected quinic acid was not aromatized, but largely excreted unchanged. 5. In rhesus monkeys pretreated with neomycin to suppress gut flora, the aromatization of oral quinic acid was considerably suppressed. 6. In rats and rhesus monkeys [14C]quinic acid was used and this confirmed its low aromatization in rats and its high aromatization in the monkeys. 7. Shikimic acid given orally was excreted as hippuric acid (26–56%) in rhesus monkeys, but not in rats. 8. The results support the view that quinic acid and shikimic acid are aromatized by the gut flora in man and the Old World monkeys.</jats:p> Species differences in the aromatization of quinic acid <i>in vivo</i> and the role of gut bacteria Biochemical Journal
spellingShingle Adamson, R. H., Bridges, J. W., Evans, M. E., Williams, R. T., Biochemical Journal, Species differences in the aromatization of quinic acid in vivo and the role of gut bacteria, General Medicine
title Species differences in the aromatization of quinic acid in vivo and the role of gut bacteria
title_full Species differences in the aromatization of quinic acid in vivo and the role of gut bacteria
title_fullStr Species differences in the aromatization of quinic acid in vivo and the role of gut bacteria
title_full_unstemmed Species differences in the aromatization of quinic acid in vivo and the role of gut bacteria
title_short Species differences in the aromatization of quinic acid in vivo and the role of gut bacteria
title_sort species differences in the aromatization of quinic acid <i>in vivo</i> and the role of gut bacteria
title_unstemmed Species differences in the aromatization of quinic acid in vivo and the role of gut bacteria
topic General Medicine
url http://dx.doi.org/10.1042/bj1160437